P21, a synthetic peptide derived from Cerebrolysin, has gained interest among self-experimenters for its potential cognitive benefits. While there is no standardized dosing protocol, various anecdotal reports provide insight into how some researchers have approached P21 administration.
Intranasal Administration
Some users prefer intranasal administration, believing it may be more effective than subcutaneous injection. One Reddit user reported using 100 mcg intranasally every few days. They noted that this microdosing approach seemed to provide benefits without significant side effects.
Subcutaneous Injection
For those opting for subcutaneous injection, dosages vary. One experimenter shared their protocol of 500 mcg per day for a 10-day course. They prepared this by reconstituting a 5 mg vial with 2.5 mL of bacteriostatic water, resulting in 25 IU daily doses.
Higher Dosages
Some researchers have explored higher dosages. A Reddit post detailed a regimen of 4 mg total daily, split into 2 mg in the morning and 2 mg at bedtime. Another user reported taking 3 mg before bed.
Dosing Frequency
Dosing frequency varies among users. While some opt for daily administration, others use P21 every few days or in cycles. One user described their approach of using P21 for about 6 weeks alongside other peptides like Semax and Selank.
Combination with Other Compounds
Many researchers combine P21 with other nootropics or peptides. One report mentioned using P21 alongside Semax, Selank, and prescription stimulants, noting improved focus and memory retention.
Safety Considerations
It’s important to note that P21 is still considered experimental, and long-term effects are not well-established. Some users have reported temporary side effects like drowsiness or mild depression, which they attribute to increased BDNF levels.
While these anecdotal reports provide interesting insights, they should not be considered medical advice or recommendations. Anyone considering P21 use should consult with a healthcare professional and approach self-experimentation with caution.
